Cancer immunotherapy aims to arm patients with immunity against cancer. Many cancer immunotherapeutic drugs have gained approval, demonstrating immunotherapy's efficacy and promise as an anticancer modality. Despite these successes, questions remain for cancer immunotherapy efficacious and cancer immunotherapy response prediction (Ning Zhang, et al. J Integr Med. 2021 Jul;19(4):291-294.) Since the modern idea of acupuncture’s immunomodulating effect seems to be promising, scientists have propounded a concept of its potential application as part of direct anti-tumor therapy (Paulina Frączek, et al. Contemp Oncol (Pozn). 2017 Jan 12;20(6):453–457). Research has revealed that acupuncture can help regulate the immune system, for example, to enhance anticancer immune function and exert anti-inflammation effects. The immunomodulatory action of acupuncture was frequently paired with additional benefits (analgesia, antiaging, antistress, etc.), which worked together to strengthen the body’s immunity ( Zeng BY, et al. Int Rev Neurobiol (2013) 111:xv–xviii.) Modern mechanism research showed that acupuncture took an anti-tumor role in promoting apoptosis of tumor cells, inhibiting proliferation, improving immunosuppression, and strengthening antioxidation (Han QQ, et al. J Cancer (2021) 12(23):7003–9. & Oura M, et al. JAMA Oncol (2021) 7(9):1399–400.). Acupuncture may stimulate anticancer immunity via activation of natural killer cells (Michael Francis Johnston, et al. Evid Based Complement Alternat Med. 2011 Mar 10;2011:481625.)