Inflammation: A Common Trigger of Liver Disease
Inflammasome activation and function in liver disease
In liver diseases, inflammasome activation is a major contributor to hepatocyte damage, immune cell activation and amplification of inflammation. This Review provides a detailed account of the different types of inflammasomes that are involved, their activation and biological functions in the context of liver injury and disease progression. Gyongyi Szabo & Jan Petrasek. Nature Reviews. Image credited to Gyongyi Szabo & Jan Petrasek. Nature Reviews.
The liver–brain axis in liver failure: neuroinflammation and encephalopathy
Hepatic encephalopathy is a severe neuropsychiatric complication of both acute and chronic liver failure. Here, the authors present new evidence that systemic and central proinflammatory mechanisms acting alone or in concert with other toxins have a role in the pathogenesis of hepatic encephalopathy. Novel diagnostic and therapeutic opportunities are also discussed. Roger F. Butterworth. Image credited to Roger F. Butterworth.
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. This Review discusses the contribution of NF-κB to chronic liver disease, with a particular focus on the role of NF-κB in different hepatic cell compartments and its effects on chronic inflammation and fibrosis as events that set the stage for the development of HCC. Tom Luedde & Robert F. Schwabe. Image credited to Tom Luedde & Robert F. Schwabe.